01 一月高分文献速递 2026年1月9日,中山大学项鹏、陈小湧、李伟强、陈莉莉团队在Cellular & Molecular Immunology上发表题为“Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models” 的研究,该研究为间充质基质细胞在改善年龄相关免疫衰退中的应用提供了新见解,并提示脾脏边缘网状细胞是关键治疗靶点。 随着人口老龄化加剧,老年人群因免疫功能衰退导致疫苗保护效力显著下降,已成为公共卫生领域的一大挑战。既往研究多聚焦于衰老相关的淋巴细胞功能减退或固有免疫衰减,而对脾脏微环境——尤其是基质细胞网络在衰老过程中的结构退化及其对疫苗应答的影响了解甚少。特别是在老年个体中,脾脏基质细胞(如边缘网状细胞,MRCs)如何随龄衰退,以及能否通过外源性干预重建其结构以增强疫苗应答,仍是该领域尚未深入探讨的关键问题。 本研究发现,输注间充质基质细胞(MSCs)可修复老年小鼠脾脏基质细胞网络与淋巴细胞结构缺陷,并能提高疫苗免疫后的特异性抗体水平,从而显著保护老年小鼠抵御流感感染。该研究不仅揭示了衰老过程中脾脏基质微环境退化是疫苗应答减弱的关键机制,还提出了一种通过外源性MSCs重建脾脏基质网络以增强老年疫苗应答的新策略。 本研究中使用了欣博盛生物(NeoBioscience Technology Co., Ltd.)提供的 Mouse IgG、IFN-γ和TNF-α ELISA试剂盒。 文献中引用的欣博盛产品如下: 货号 名称 灵敏度 检测范围 QuantiCyto® Mouse IgG(Total) ELISA kit 0.078 ng/ml 0.156-10 ng/ml QuantiCyto® Mouse IFN-γ ELISA kit 3.9 pg/ml 7.8-500 pg/ml QuantiCyto® Mouse TNF-αELISA kit 15.6 pg/ml 31.25-2000 pg/ml


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02 一月文献引用合集
1. Mesenchymal stromal cells counteract with age-related immune decline and enhance vaccine efficacy by modulating endogenous splenic marginal reticular cells in elderly models(Cellular & Molecular Immunology,IF=19.8)
发表时间:2026-01-09
作者单位:中山大学
引用产品:Mouse IgG ELISA Kit、Mouse IFN-γ ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IgG、IFN-γ、TNF-α
样本类型:serum、lung bronchoalveolar lavage fluid (BALF)
原文链接:https://www.nature.com/articles/s41423-025-01381-9
2. Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides(Advanced Science,IF=14.1)
发表时间:2026-01-12
作者单位:西安交通大学第一附属医院
引用产品:Rat IgG ELISA Kit、Rat IgM ELISA Kit
靶标:IgG、IgM
样本类型:serum
原文链接:https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/advs.202517068
3. CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization(Theranostics,IF=13.3)
发表时间:2026-01-01
作者单位:中国医学科学院药物研究所
引用产品:Rat TGF-β1 ELISA Kit
靶标:TGF-β1
样本类型:platelet
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12674933/
4. The self-assembling amphibian-derived peptide (RADA)4-FZ1 pioneers a novel therapeutic platform for diabetic skin wound management(CHEMICAL ENGINEERING JOURNAL,IF=13.2)
发表时间:2026-01-24
作者单位:昆明医科大学
引用产品:Mouse IL-1β ELISA Kit、Mouse TGF-β1 ELISA Kit、Mouse IL-6 ELISA Kit、Mouse IL-10 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-1β、TGF-β1、IL-6、IL-10、TNF-α
样本类型:RAW264.7 cell、skin tissue
原文链接:https://www.sciencedirect.com/science/article/pii/S138589472600690X
5. TNFSF10 drives hyperactive immune responses via NLRP3 inflammasome and endoplasmic reticulum stress in autoimmune and inflammatory diseases(Journal of Advanced Research,IF=13.0)
发表时间:2026-01-16
作者单位:郑州大学第一附属医院
引用产品:Human IFN-β ELISA Kit、Human IL-29(IFN-λ) ELISA Kit、Human IFN-α ELISA Kit
靶标:IFN-β、IFN-λ、IFN-α
样本类型:plasma
原文链接:https://www.sciencedirect.com/science/article/pii/S2090123226000548
6. Friction-Adaptive Hydrogel Coating for Mechanical-Immune Synergy in Ligament-to-Bone Integration(BIOMATERIALS,IF=12.9)
发表时间:2026-01-21
作者单位:华东理工大学
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit、Mouse IL-10 ELISA Kit、Mouse TGF-β1 ELISA Kit
靶标:TNF-α、IL-6、IL-10、TGF-β1
样本类型:knee joint tissue
原文链接:https://www.sciencedirect.com/science/article/pii/S014296122600027X
7. Photo-controlled spatiotemporal sequential release of MXenes/NO gas from bilayer (clean-cure) hydrogel promotes healing of MRSA biofilm-infected diabetic ulcer wounds(JOURNAL OF CONTROLLED RELEASE,IF=11.5)
发表时间:2026-01-06
作者单位:华侨大学
引用产品:Mouse IL-6 ELISA Kit、Mouse IL-10 ELISA Kit、Mouse TGF-β1 ELISA kit、Mouse TNF-α ELISA Kit
靶标:IL-6、IL-10、TGF-β1、TNF-α
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S016836592600012X
8. Mannosylated siRNA/PERKi nanoassemblies reprogram macrophages to block tumor metastasis(Nano Today,IF=10.9)
发表时间:2026-01-14
作者单位:上海交通大学
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-12p70 ELISA Kit、Mouse TGF-β ELISA Kit、Mouse IL-10 ELISA Kit
靶标:TNF-α、IL-12p70、TGF-β、IL-10
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S1748013226000022
9. Xiaoyaosan and isoliquiritigenin remodel depression-associated chromatin 3D structure and phase separation of NF-κB1(PHARMACOLOGICAL RESEARCH,IF=10.5)
发表时间:2026-01-23
作者单位:暨南大学
引用产品:Mouse IL-1β ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-1β、TNF-α
样本类型:BV2 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S1043661826000265
10. Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling(Materials Today Bio,IF=10.2)
发表时间:2026-01-21
作者单位:上海大学
引用产品:Human BMP-4 ELISA Kit
靶标:BMP-4
样本类型:BMP-4-loaded nanoparticles-biodegradable mesoporous silica nanoparticles (B@M-bMSN)
原文链接:https://www.sciencedirect.com/science/article/pii/S2590006426000803
11. An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzheimer's disease therapy(Materials Today Bio,IF=10.2)
发表时间:2026-01-31
作者单位:浙江大学医学院附属妇产科医院
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit
靶标:TNF-α、IL-6
样本类型:brain tissue、serum
原文链接:https://www.sciencedirect.com/science/article/pii/S2590006426001171
12. A Tumor Cell Membrane-Coated CD40 Ligand-Encoding Oncolytic Adenovirus Serves as a Potent Nano-Vaccine for Ovarian Cancer Immunotherapy(Advanced Healthcare Materials,IF=9.6)
发表时间:2026-01-19
作者单位:同济医院
引用产品:Human HMGB1 ELISA Kit、Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit、Mouse IL-10 ELISA Kit、Mouse TGF-β1 ELISA Kit
靶标:HMGB-1、IL-6、TNF-α、IL-10、TGF-β1
样本类型:ascitic fluid、OVCAR-8 cell、Serum、RAW264.7 cell
原文链接:https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202503175
13. Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway(INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,IF=8.5)
发表时间:2026-01-08
作者单位:广西中医药大学
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit
靶标:TNF-α、IL-6
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0141813026000929
14. Panax Notoginseng Saponins Ameliorate Spinal Cord Injury by Inhibiting JAK2/STAT3-Mediated Macrophage Polarization: Enhanced Delivery by Ultrasound-targeted Microbubble Destruction(PHYTOMEDICINE,IF=8.3)
发表时间:2026-01-20
作者单位:四川大学附属成都市第二人民医院
引用产品:Mouse IL-6 ELISA Kit、Mouse IL-10 ELISA Kit
靶标:IL-6、IL-10
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0944711326000966
15. Synergistic bone regeneration via dual growth factor-loaded chitosan/anorganic bovine xenograft scaffolds with different pore structures(MATERIALS & DESIGN,IF=7.9)
发表时间:2026-01-13
作者单位:苏州大学附属第一医院、南京大学医学院附属金陵医院、第四军医大学
引用产品:Human BMP-7 ELISA Kit、Human PDGF ELISA Kit
靶标:BMP-7、PDGF
样本类型:C/ABX/BMP-7 scaffold、C/ABX/BMP-7/PDGF scaffold
原文链接:https://www.sciencedirect.com/science/article/pii/S0264127526000602
16. Rho-related GTP-binding protein RhoE (RND3) regulates multiple myeloma bone disease(Cancer Cell International,IF=6.0)
发表时间:2026-01-07
作者单位:四川大学华西医院
引用产品:Human MMP-9 ELISA Kit
靶标:MMP-9
样本类型:myeloma (MM) cell
原文链接:https://link.springer.com/article/10.1186/s12935-025-04166-2
17. A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities(Frontiers in Immunology,IF=5.9)
发表时间:2026-01-14
作者单位:广西医科大学、广西医科大学第一附属医院
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit、Mouse IL-1β ELISA Kit
靶标:TNF-α、IL-6、IL-1β
样本类型:liver tissue
原文链接:https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1711388/full
18. Aggregatibacter actinomycetemcomitans exacerbates colitis and perturbs the gut microbiota in a murine model(Journal of Oral Microbiology,IF=5.5)
发表时间:2026-01-11
作者单位:南京医科大学、南京医科大学附属口腔医院
引用产品:Mouse IL-1β ELISA Kit、Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-1β、IL-6、TNF-α
样本类型:serum
原文链接:https://www.tandfonline.com/doi/abs/10.1080/20002297.2026.2613536
19. CoCrMo Particles Drive Macrophage Ferroptosis via Inhibiting the Sirtuin 1/NRF2/GPX4 Pathway to Promote Periprosthetic Inflammatory Osteolysis(ACS Biomaterials Science & Engineering,IF=5.5)
发表时间:2026-01-14
作者单位:南方医科大学
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit
靶标:TNF-α、IL-6
样本类型:BMDMs
原文链接:https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5c01694
20. Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial(Food & Function,IF=5.4)
发表时间:2026-01-22
作者单位:南方医科大学
引用产品:Human MCP-1 ELISA Kit
靶标:MCP-1
样本类型:blood
原文链接:https://pubs.rsc.org/en/content/articlelanding/2026/fo/d5fo04037j
21. Exploring the mechanism of dihydromyricetin in alleviating psoriasis based on metabolomics, network pharmacology and experimental validation(JOURNAL OF ETHNOPHARMACOLOGY,IF=5.4)
发表时间:2026-01-14
作者单位:沈阳药科大学
引用产品:Mouse IL-17 ELISA Kit
靶标:IL-17
样本类型:skin tissue、serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0378874126000188
22. Ethyl acetate fraction from Dendrobium officinale inhibits IL-17A signaling pathway to mitigate acute lung injury(JOURNAL OF ETHNOPHARMACOLOGY,IF=5.4)
发表时间:2026-01-09
作者单位:杭州医学院
引用产品:Mouse IL-6 ELISA Kit、Mouse IL-1β ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-6、IL-1β、TNF-α
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0378874126000279
23. Targeting microglial inflammation in Parkinson’s disease: irisin activates PAFAH1B1-RAGE ubiquitination and TFEB-dependent autophagy to alleviate neurodegeneration(Communications Biology,IF=5.1)
发表时间:2026-01-10
作者单位:贵州省医科大学附属医院
引用产品:Mouse TNF-α ELISA Kit、Mouse IL-12/23p40 ELISA Kit、Mouse IL-1β ELISA Kit、Mouse IL-4 ELISA Kit、Mouse IL-10 ELISA Kit
靶标:TNF-α、IL-12/23p40、IL-1β、IL-4、IL-10
样本类型:serum、BV2 cell
原文链接:https://www.nature.com/articles/s42003-025-09389-7
24. ERN2/XBP1-AGR2 mediated endoplasmic reticulum stress increased neutrophilic asthma mucus secretion(INTERNATIONAL IMMUNOPHARMACOLOGY,IF=4.7)
发表时间:2026-01-02
作者单位:广州中医药大学、广州中医药大学第一附属医院
引用产品:Mouse IL-6 ELISA Kit、Mouse IL-8 ELISA Kit、Mouse TNF-α ELISA Kit、Mouse IgE ELISA Kit、Mouse IFN-γ ELISA Kit、Mouse IL-17 ELISA Kit、Mouse IL-33 ELISA Kit
靶标:IL-6、IL-8、TNF-α、IgE、IFN-γ、IL-17、IL-33
样本类型:Bronchoalveolar lavage fluid (BALF)、serum
原文链接:https://www.sciencedirect.com/science/article/pii/S1567576925021228
25. BvrR From Brucella abortus Induces Neuroinflammation Through IRE1‐Mediated Activation of ATF2 and NF‐κB(MicrobiologyOpen,IF=4.6)
发表时间:2026-01-21
作者单位:空军军医大学第二附属医院
引用产品:Human IL-6 ELISA Kit、Human TNF-α ELISA Kit
靶标:IL-6、TNF-α
样本类型:HMC3 cell
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12823783/
26. Gut microbiota dysbiosis aggravates sepsis-induced lung injury by promoting neutrophil extracellular traps and suppressing host integrin defense(Frontiers in Microbiology,IF=4.5)
发表时间:2026-01-09
作者单位:山西医科大学第三医院、山西医科大学第一医院
引用产品:Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-6、TNF-α
样本类型: MPMECs
原文链接:https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1699748/full
27. Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2-Related Factor 2(DRUG DEVELOPMENT RESEARCH,IF=4.2)
发表时间:2026-01-04
作者单位:荆州市中心医院
引用产品:Mouse IL-1β ELISA Kit、Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-1β、IL-6、TNF-α
样本类型:serum
原文链接:https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/ddr.70223
28. TRIM52 Protects Against Doxorubicin‐Induced Cardiac Inflammation, Oxidative Stress and Cardiac Injury(JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,IF=4.2)
发表时间:2026-01-09
作者单位:宁波大学附属第一医院
引用产品:Mouse IL-1β ELISA Kit、Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-1β、IL-6、TNF-α
样本类型:serum、heart tissue
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12784278/
29. Polystyrene Microplastics Disrupt Vertical Transmission of the Breast Milk Microbiome, Impairing Early-Life Gut Colonization and Immune Development in Offspring(FASEB JOURNAL,IF=4.2)
发表时间:2026-01-09
作者单位:湖州大学医学院第一附属医院
引用产品:Mouse IL-6 ELISA Kit、Mouse IgM ELISA Kit
靶标:IL-6、IgM
样本类型:serum
原文链接:https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202503819R
30. The mechanism of indigo naturalis and its active ingredients against ulcerative colitis(Scientific Reports,IF=3.9)
发表时间:2026-01-14
作者单位:陕西中医药大学、空军军医大学唐都医院
引用产品:Mouse IL-1β ELISA Kit、Mouse IL-10 ELISA Kit、Mouse TNF-α ELISA Kit、Mouse IL-6 ELISA Kit
靶标:IL-1β、IL-10、TNF-α、IL-6
样本类型:serum、RAW264.7 cell
原文链接:https://www.nature.com/articles/s41598-026-35413-9
31. BvrR of Brucella initiates microglial inflammation through the activation of the IRE1 pathway(MICROBIAL PATHOGENESIS,IF=3.5)
发表时间:2026-01-21
作者单位:空军军医大学第二附属医院
引用产品:Human IL-6 ELISA Kit、Human TNF-α ELISA Kit
靶标:IL-6、TNF-α
样本类型:HMC3 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0882401026000392
32. Salidroside derivative SHPL-49 accelerates cutaneous wound healing in diabetic mice by modulating macrophage-mediated TGF-β1/Smad2/3 signaling pathway(TOXICOLOGY AND APPLIED PHARMACOLOGY,IF=3.4)
发表时间:2026-01-02
作者单位:上海中医药大学
引用产品:Mouse TGF-β1 ELISA Kit
靶标:TGF-β1
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0041008X25004752
33. The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis(Current Research in Toxicology,IF=3.0)
发表时间:2026-01-22
作者单位:秦皇岛市第一医院
引用产品:Mouse IL-1β ELISA Kit、Mouse IL-18 ELISA Kit
靶标:IL-1β、IL-18
样本类型:serum、BALF
原文链接:https://www.sciencedirect.com/science/article/pii/S2666027X26000034
34. Apigenin ameliorates atherosclerosis by inhibiting macrophage foam cell formation in ApoE−/−mice fed a high fat diet(ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,IF=3.0)
发表时间:2026-01-08
作者单位:西安交通大学、国药东风总医院
引用产品:Mouse IL-6 ELISA Kit、Mouse TNF-α ELISA Kit
靶标:IL-6、TNF-α
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0003986126000019
35. SVA virus-like vesicle vaccine based on VEEV-VSVG vector elicits efficient immune responses and protection in swine(VETERINARY MICROBIOLOGY,IF=2.7)
发表时间:2026-01-14
作者单位:华中农业大学
引用产品:Swine IL-2 ELISA Kit、Swine IFN-γ ELISA Kit、Swine IL-10 ELISA Kit
靶标:IL-2、IFN-γ、IL-10
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0378113525004985
36. Ameliorating Effects of Murraya paniculata (L.) Jack Extract on Arthritis via Suppressing Multi-Target-Mediated Synovial Hyperplasia, Inflammation, and Oxidative Stress(PHYTOCHEMICAL ANALYSIS,IF=2.6)
发表时间:2026-01-15
作者单位:澳门大学
引用产品:Rat immunoglobulin A (IgA) ELISA Kit、Rat immunoglobulin G (IgG) ELISA Kit、Rat IL-1β ELISA Kit、Rat IL-2 ELISA Kit、Rat MCP-1 ELISA Kit、Rat IL-4 ELISA Kit、Human TNF-α ELISA Kit、Human IL-6 ELISA Kit、Human IL-8 ELISA Kit、Human IL-1β ELISA Kit
靶标:IgA、IgG、IL-1β、IL-2、MCP-1、IL-4、TNF-α、IL-6、IL-8
样本类型:rat serum、SW982 cell
原文链接:https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/pca.70048
37. The SIRT1-HMGB1 pathway in hippocampal microglia is involved in chronic heroin-induced cognitive impairment(PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,IF=2.5)
发表时间:2026-01-21
作者单位:贵州医科大学
引用产品:Mouse HMGB-1 ELISA Kit
靶标:HMGB-1
样本类型:hippocampus tissue
原文链接:https://www.sciencedirect.com/science/article/pii/S0091305726000109



