近期,华中科技大学张建成副教授、袁世荧教授与尚游教授团队在Nature Communications(IF=14.7)上发表题为“Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury in mice”的研究。脓毒症(Sepsis)是一个严重的全球性健康问题,通常由急性肺损伤(ALI)或急性呼吸窘迫综合征(ARDS)引起。虽然肠-肺轴在ALI中的作用已有报道,但肠道免疫细胞直接迁移到肺部的过程仍然不明确。研究团队发现,脓毒症诱导的γδ T17细胞从小肠迁移到肺部,引发了小鼠体内以IL-17A为主导的炎症反应。肺泡巨噬细胞中Wnt信号通路的激活促进了CCL1的上调,从而促进γδ T17细胞的迁移。CD44+ Ly6C- IL-7Rhigh CD8low细胞是加重ALI症状的主要迁移亚型。艾司氯胺酮(Esketamine)通过抑制肺部Wnt/β-catenin信号通路介导的迁移来减轻ALI。该项研究强调了肠-肺记忆γδ T17细胞迁移在脓毒性ALI中的关键作用,并阐明了肺部局部IL-17A升高的重要性。
该项研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的Mouse IL-6, TNF-α和IL-17/IL-17A ELISA Kits,用于检测相关指标含量。
货号 | 产品名称 | 灵敏度 | 检测范围 |
QuantiCyto® Mouse IL-6 ELISA kit(小鼠白细胞介素-6) | 7.8pg/ml | 15.6-1000pg/ml | |
QuantiCyto® Mouse TNF-α ELISA kit(小鼠肿瘤坏死因子-α) | 15.6pg/ml | 31.25-2000pg/ml | |
QuantiCyto® Mouse IL-17/IL-17A ELISA kit(小鼠白细胞介素-17/IL-17A) | 7.8pg/ml | 15.6-1000pg/ml |
欣博盛生物作为供应商,为该研究提供了高质量ELISA试剂盒。这不仅帮助了研究团队在实验中取得可靠的数据,也彰显了我们致力于支持生物医学领域科研进展的承诺。
2024年8月文献引用
1. Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury in mice.(Nature Communications, IF=14.7)
发表时间:2024/8/7
作者:Xie B, Wang M, Zhang X, et al.
作者单位:华中科技大学
使用产品:Mouse IL-6, TNF-α and IL-17/IL-17A ELISA Kits
样本类型:支气管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/39112475/
2. Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.(Nature Communications, IF=14.7)
发表时间:2024/8/27
作者:Qiu J, Ma J, Dong Z, et al.
作者单位:中国科学院生态环境研究中心
使用产品:Mouse IL-6 and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39191805/
3. Biodegradable Persistent Luminescence Nanoparticles as Pyroptosis Inducer for High-Efficiency Tumor Immunotherapy.(Advanced Science, IF=14.3)
发表时间:2024/8/19
作者:Liu L, Shi J, Wang J, et al.
作者单位:中国科学院福建物质结构研究所
使用产品:Mouse IL-1β, IL-6, IL-10, IL-12p70, TNF-α and INF-γ ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39158490/
4. Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells.(Journal of Hazardous Materials, IF=12.2)
发表时间:2024/8/15
作者:Chen X, Chen H, Zhang P, et al.
作者单位:青岛大学
使用产品:Mouse IgE ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39154481/
5. Machine learning-based analysis identifies and validates serum exosomal proteomic signatures for the diagnosis of colorectal cancer.(Cell Reports Medicine, IF=11.7)
发表时间:2024/8/20
作者:Yin H, Xie J, Xing S, et al.
作者单位:中山大学附属第七医院
使用产品:Human CXCL4/PF4 ELISA kit
样本类型:细胞外囊泡
https://pubmed.ncbi.nlm.nih.gov/39168094/
6. Chitosan/dextran-based organohydrogel delivers EZH2 inhibitor to epigenetically reprogram chemo/immuno-resistance in unresectable metastatic melanoma.(Carbohydrate Polymers, IF=10.7)
发表时间:2024/8/22
作者:Tang Q, Leng S, Tan Y, et al.
作者单位:中山大学
使用产品:Mouse TNF-α, IL-6 and IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0144861724008713
7. A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain.(Journal of Nanobiotechnology, IF=10.6)
发表时间:2024/8/14
作者:Li K, Yang W, Chen X, et al.
作者单位:华中科技大学同济医学院附属协和医院
使用产品:Rat TNF-α, IFN-γ, IL-1β and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39143545/
8. An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas.(Journal of Controlled Release, IF=10.5)
发表时间:2024/8/29
作者:Tan Y, Lai T, Li Y, et al.
作者单位:华中科技大学同济医学院附属协和医院
使用产品:Rat IL-4, IL-1β, MIP-1α and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0168365924005807
9. Caulerpa chemnitzia polysaccharide exerts immunomodulatory activity in macrophages by mediating the succinate/PHD2/HIF-1α/IL-1β pathway.(International Journal of Biological Macromolecules, IF=7.7)
发表时间:2024/8/3
作者:Zeng J, Liu J, Zhao N, et al.
作者单位:华南农业大学
使用产品:Mouse IL-1β, IL-6, TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39098690/
10. Galacto-oligosaccharides modified whey protein isolate ameliorates cyclophosphamide-induced immunosuppression.(International Journal of Biological Macromolecules, IF=7.7)
发表时间:2024/8/10
作者:Mao J, Wang Y, Chen W, et al.
作者单位:江西师范大学
使用产品:Mouse IFN-γ and IL-1β ELISA Kits
样本类型:肠组织
https://pubmed.ncbi.nlm.nih.gov/39128745/
11. Polydatin and chitosan-silver co-loaded nanocomplexes for synergistic treatment of rheumatoid arthritis via repolarizing macrophages and inducing apoptosis of fibroblast-like synoviocytes.(Materials & Design, IF=7.6)
发表时间:2024/8/30
作者:Su Z, Tang Y, Li G, et al.
作者单位:湖南中医药大学第一附属医院
使用产品:Mouse TNF-α, IL-6, and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0264127524006622
12. Evening primrose and its compounds of 1-Oxohederagenin and remangilone C ameliorate bleomycin-induced pulmonary fibrosis by regulating β-catenin signaling.(Phytomedicine, IF=6.7)
发表时间:2024/8/3
作者:Zhang Q, Zeng M, Zhang B, et al.
作者单位:河南中医药大学
使用产品:Rat IL-1β, TNF-α and TGF-β1 ELISA kits
样本类型:支气管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/39121537/
13. Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen.(Ecotoxicology and Environmental Safety, IF=6.2)
发表时间:2024/8/28
作者:Ran X, Yan X, Ma G, et al.
作者单位:贵州医科大学
使用产品:Rat IL-6 ELISA kit
样本类型:脾脏组织
https://www.sciencedirect.com/science/article/pii/S0147651324009898
14. ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation.(Journal of Translational Medicine, IF=6.1)
发表时间:2024/8/22
作者:Song D, Zhou X, Yu Q, et al.
作者单位:川北医学院附属医院
使用产品:Mouse IL-1β, TNF-α, IL-6 and CCL2 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39175013/
15. Pterostilbene Alleviates Dextran Sodium Sulfate (DSS)-Induced Intestinal Barrier Dysfunction Involving Suppression of a S100A8-TLR-4-NF-κB Signaling Cascade.(Journal of Agricultural and Food Chemistry, IF=5.7)
发表时间:2024/8/6
作者:Lv K, Song J, Wang J, et al.
作者单位:天津商业大学
使用产品:Mouse TNF-α, IL-1β and IL-6 ELISA Kits
样本类型:结肠组织
https://pubmed.ncbi.nlm.nih.gov/39106077/
16. Development of Hypoallergenic Derivatives of Cra a 1 with B Cell Epitope Deletion and T Cell Epitope Retention.(Journal of Agricultural and Food Chemistry, IF=5.7)
发表时间:2024/8/21
作者:Huan F, Gao S, Ni L N, et al.
作者单位:厦门大学
使用产品:Mouse IL-2, IL-4, IFN-γ and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39168117/
17. Probiotics suppress LL37 generated rosacea-like skin inflammation by modulating the TLR2/MyD88/NF-κB signaling pathway.(Food & Function, IF=5.1)
发表时间:2024/8/15
作者:Qi X, Xiao Y, Zhang X, et al.
作者单位:南昌大学
使用产品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/39143863/
18. TgMIC6 inhibition of autophagy is partially responsible for the phenotypic differences between Chinese 1 Toxoplasma gondii strains.(International Immunopharmacology, IF=4.8)
发表时间:2024/8/7
作者:Wang Y, Li J, Zhu J, et al.
作者单位:安徽医科大学
使用产品:Mouse IFN-γ, IL-12, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39116491/
19. Dendrobium officinale Kimura et Migo polysaccharide ameliorated DNFB-induced atopic dermatitis in mice associated with suppressing MAPK/NF-κB/STAT3 signaling pathways.(Journal of Ethnopharmacology, IF=4.8)
发表时间:2024/8/8
作者:Liao J, Zhao W, Zhang Y, et al.
作者单位:华南农业大学
使用产品:Mouse TNF-α, IFN-γ, IL-1β, IL-4, IL-5 and IL-13 ELISA Kits
样本类型:皮肤组织
https://pubmed.ncbi.nlm.nih.gov/39121927/
20. Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway.(Natural Products and Bioprospecting, IF=4.8)
发表时间:2024/8/12
作者:Yang S, Huang J, Tan W, et al.
作者单位:中南民族大学
使用产品:Mouse IL-10, TNF-α, IL-6 and IL-1β ELISA Kits
样本类型:结肠组织
https://pubmed.ncbi.nlm.nih.gov/39133435/
21. Bay-117082 treats sepsis by inhibiting neutrophil extracellular traps (NETs) formation through down-regulating NLRP3/N-GSDMD.(International Immunopharmacology, IF=4.8)
发表时间:2024/8/14
作者:Zou S, Han X, Luo S, et al.
作者单位:南方医科大学第三附属医院
使用产品:Mouse IL-1β and IL-6 ELISA Kits
样本类型:支气管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/39146778/
22. A comparison of the physicochemical properties, allergenicity, and stability of recombinant β-lactoglobulin: Development of standard bovine milk allergens.(Food Bioscience, IF=4.8)
发表时间:2024/8/18
作者:Xie F, Hu W, Meng X, et al.
作者单位:南昌大学
使用产品:Mouse IL-4 ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S2212429224013865
23. The function and mechanism of Human nasal mucosa-derived mesenchymal stem cells in allergic rhinitis in mice.(Inflammation Research, IF=4.8)
发表时间:2024/8/24
作者:Liu Y, Liu S, Meng L, et al.
作者单位:山东省耳鼻喉医院
使用产品:Mouse IgE ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/39180692/
24. Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordoma.(Cancer Immunology, Immunotherapy, IF=4.6)
发表时间:2024/8/2
作者:Wu H, Xu Z, Qi M, et al.
作者单位:首都医科大学宣武医院
使用产品:Human IL-2, IFN-γ, IL-6, IL-7 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39093440/
25. Ethanol Extract of Propolis Attenuates Liver Lipid Metabolism Disorder in High-Fat Diet-Fed SAMP8 Mice.(Molecular Nutrition & Food Research, IF=4.5)
发表时间:2024/8/20
作者:Xie Q, Shu X, Liu T, et al.
作者单位:南昌大学
使用产品:Mouse KC(IL-8) ELISA kit
https://pubmed.ncbi.nlm.nih.gov/39165040/
26. Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer.(Translational Oncology, IF=4.5)
发表时间:2024/8/24
作者:Wang L, Zhang X, Chen S, et al.
作者单位:香港大学深圳医院
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/pii/S1936523324002304
27. Augmented type 2 inflammatory response in allergic rhinitis patients experiencing systemic reactions to house dust mite subcutaneous immunotherapy.(Pediatric Allergy and Immunology, IF=4.3)
发表时间:2024/8/1
作者:Ji P, Yang L, Zhu L, et al.
作者单位:华中科技大学同济医学院
使用产品:Human IL-1β, IL-2, IL-4, IL-10, IL-13, IL-17, IL-25, IL-33, IFN-γ and TSLP ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39092594/
28. Aucubin suppresses TLR4/NF-κB signalling to shift macrophages toward M2 phenotype in glucocorticoid-associated osteonecrosis of the femoral head.(Journal of Cellular and Molecular Medicine, IF=4.3)
发表时间:2024/8/1
作者:Yue C, Cui G, Cheng Y, et al.
作者单位:河南省骨科医院
使用产品:Human IL‐1β and IL‐6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39123292/
29. Fermented sea buckthorn compound juice inhibits colorectal cancer growth by regulating immunity and the gut microbiome.(Journal of Functional Foods, IF=3.8)
发表时间:2024/8/23
作者:Fu Y, Liu Z, Wang K, et al.
作者单位:沈阳药科大学
使用产品:Mouse TNF-α, IFN-γ, IL-1β, IL-6 and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/pii/S1756464624004109
30. Proinflammatory Effect of Membrane Vesicles Derived from Enterococcus faecalis at Neutral and Alkaline pH.(Journal of Endodontics, IF=3.5)
发表时间:2024/8/30
作者:Niu C, Huang J, Wei L, et al.
作者单位:上海交通大学医学院附属第九人民医院
使用产品:Human IL-1β, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/pii/S0099239924004801
31. Breaking the chain in organ failure: Role of umbilical cord and bone marrow derived mesenchymal stem cells in treatment of severe acute pancreatitis.(Heliyon, IF=3.4)
发表时间:2024/8/9
作者:Ren R, Ren W, Zhang Y, et al.
作者单位:中国人民解放军总医院
使用产品:Mouse IL-6, MCP-1, IL-1β, TNF-α and IL-10 ELISA Kits
样本类型:胰腺组织;肾脏组织;肺组织;心脏组织
https://www.sciencedirect.com/science/article/pii/S2405844024118166
32. Tuberostemonine may alleviates proliferation of lung fibroblasts caused by pulmonary fibrosis.(International Journal of Immunopathology and Pharmacology, IF=3)
发表时间:2024/8/14
作者:Tang A, Liu Y, Ding Q, et al.
作者单位:贵州中医药大学第一附属医院
使用产品:Mouse MIP-2/CXCL2 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/39140804/
33. Modulating tumor-associated macrophage polarization by anti-maRCO mAb exerts anti-osteosarcoma effects through regulating osteosarcoma cell proliferation, migration and apoptosis.(Journal of Orthopaedic Surgery and Research, IF=2.8)
发表时间:2024/7/31
作者:Ding L, Wu L, Cao Y, et al.
作者单位:复旦大学附属金山医院
使用产品:Human TNF-α, IL-1β, IL-6, and IL-23 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/39085912/
34. Protopine-Type Alkaloids Alleviate Lipopolysaccharide-Induced Intestinal Inflammation and Modulate the Gut Microbiota in Mice.(Animals, IF=2.7)
发表时间:2024/8/5
作者:Huang J, Yue M, Yang Y, et al.
作者单位:山西农业大学
使用产品:Mouse IL-8 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/39123799/