
01 十一月高分文献速递
2025年11月15日,国际细胞生物学权威期刊Autophagy (IF 14.3) 发表了武汉大学周荣家教授与程汉华教授课题组的最新研究成果,论文题为《Mitochondrial NAD⁺-mediated mitophagy alleviates type I interferon response to the cytosolic mitochondrial DNA》,该研究揭示了线粒体NAD+调控线粒体自噬及维持细胞稳态的分子机制和功能。

✍ 线粒体烟酰胺腺嘌呤二核苷酸(NAD⁺)在能量代谢中发挥核心作用,但其在线粒体自噬及固有免疫中的功能与作用机制仍不清楚。本研究发现,线粒体NAD⁺缺乏会引发线粒体自噬功能异常与炎症反应。研究证实,线粒体NAD⁺转运蛋白SLC25A51 缺失导致的线粒体NAD⁺耗竭,损伤BNIP3介导的线粒体自噬。线粒体NAD⁺的缺失会抑制SIRT3介导的FOXO3去乙酰化作用,进而导致BNIP3的转录水平下调,并阻碍MAP1LC3B/LC3B的募集。值得注意的是,在氧化应激下,线粒体NAD+缺乏会促进线粒体DNA(mtDNA)从线粒体释放到细胞质中,进而通过激活CGAS-STING1信号通路,加剧胞质游离mtDNA诱导的Ⅰ型干扰素应答。本研究通过细胞系的基因操作揭示了线粒体NAD⁺、线粒体自噬与mtDNA诱导炎症反应三者间全新的分子调控关联,表明线粒体NAD⁺有望成为缓解胞质游离mtDNA所引发无菌性炎症的潜在治疗靶点。因此,该研究为线粒体稳态、炎症和先天免疫之间的相互作用提供了新的见解。
✍ 在本研究中,使用了欣博盛生物(NeoBioscience Technology Co., Ltd.)提供的 Human IFN-β、CCL5和CXCL10 ELISA kit。


文献中引用的欣博盛产品如下:
货号 | 名称 | 灵敏度 | 检测范围 |
QuantiCyto® Human IFN-β ELISA kit | 0.16pg/ml | 0.313-20ng/ml | |
EHC143 | QuantiCyto® Human RANTES/CCL5 ELISA kit | 1,95pg/ml | 3.9-250pg/ml |
EHC157 | QuantiCyto® Human IP-10/CXCL10 ELISA kit | 1.95pg/ml | 3.9-250pg/ml |
✍ 欣博盛生物作为供应商,为科研工作者提供高质量ELISA试剂盒,确保每一批次产品的高质量与稳定性。致力于提供最优质的产品和服务,助力您的科研迈向新的高度!
02 十一月文献引用合集
1. Mitochondrial NAD⁺-mediated mitophagy alleviates type I interferon response to the cytosolic mitochondrial DNA(Autophagy, IF = 14.3)
发表时间:2025-11-15
作者单位:武汉大学
引用产品:Human IFN-β ELISA Kit、Human CCL5 ELISA Kit、Human CXCL10 ELISA Kit
样本类型:HeLa cell
原文链接:https://www.tandfonline.com/doi/abs/10.1080/15548627.2025.2589909
2. Quercetin-loaded milk-derived extracellular vesicles for the treatment of inflammatory bowel disease by alleviating senescence-associated cell cycle arrest(CHEMICAL ENGINEERING JOURNAL, IF = 13.2)
发表时间:2025-11-13
作者单位:西北工业大学
引用产品:Mouse IL-1β ELISA kit、Mouse IL-6 ELISA kit、Mouse TNF-α ELISA kit、Mouse IL-10 ELISA kit、Mouse TGF-β ELISA kit
样本类型:Colon tissue
原文链接:https://www.sciencedirect.com/science/article/pii/S1385894725117051
3. Apoptotic extracellular vesicles derived from mesenchymal stromal cells encapsulated in chitosan-modified hydrogels with multiple and sequential regulatory functions for infected wound healing(CHEMICAL ENGINEERING JOURNAL, IF = 13.2)
发表时间:2025-11-24
作者单位:第四军医大学口腔医学院
引用产品:Mouse VEGF ELISA kit、Mouse FGF ELISA kit、Mouse PDGF-BB ELISA kit
样本类型:bone marrow derived macrophages (BMDMs)
原文链接:https://www.sciencedirect.com/science/article/pii/S1385894725120780
4. H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2⁺ Treg recruitment(EXPERIMENTAL AND MOLECULAR MEDICINE, IF = 12.9)
发表时间:2025-11-28
作者单位:华中科技大学同济医学院附属协和医院
引用产品:Human CCL17 ELISA Kit、Human CCL22 ELISA Kit、Human CXCL16 ELISA Kit
样本类型:malignant pleural effusion (MPE), peripheral blood (PB)
原文链接:https://www.nature.com/articles/s12276-025-01557-3
5. Targeted suppression of CCR7/NF-κB signaling by apoptotic body-inspired colchicine nanovesicles halts atherosclerotic progression(JOURNAL OF NANOBIOTECHNOLOGY, IF = 12.6)
发表时间:2025-11-25
作者单位:暨南大学第一附属医院、暨南大学
引用产品:Mouse TNF-α ELISA kit、Mouse IL-6 ELISA kit、Mouse IL-18 ELISA kit
样本类型:serum, RAW 264.7 cell
原文链接:https://pubmed.ncbi.nlm.nih.gov/41291734/
6. CD5 ablation enhances persistence and antitumor potency of engineered T cells by mitigating exhaustion and promoting cytotoxicity(Journal for ImmunoTherapy of Cancer, IF = 10.6)
发表时间:2025-11-29
作者单位:华中科技大学同济医学院附属同济医院
引用产品:Human IFN-γ ELISA kit、Human TNF-α ELISA kit
样本类型:T cell
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12666075/
7. Magnetic Hydrogel: Enhanced Bacterial Biosensor for Speedy Gut Disease Detection(ACS Sensors, IF = 9.1)
发表时间:2025-11-19
作者单位:浙江工业大学
引用产品:Mouse TNF-α ELISA kit、Mouse IL-6 ELISA kit
样本类型:serum, RAW 264.7 cell
原文链接:https://pubs.acs.org/doi/abs/10.1021/acssensors.5c01813
8. Dextran based hydrogel wound dressing with cytocompatible, anti-protein and antibacterial properties for infected wound healing(INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, IF = 8.5)
发表时间:2025-11-07
作者单位:上海市皮肤病医院
引用产品:Mouse IL-1β ELISA kit、Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0141813025092669
9. Single-cell analysis integrated with RNA-Sequencing uncovers new action of Patchoulol on adipose tissue remodeling in obesity(PHYTOMEDICINE, IF = 8.3)
发表时间:2025-11-26
作者单位:成都中医药大学
引用产品:Mouse TNF-α ELISA kit、Mouse IL-10 ELISA kit
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0944711325012474
10. CXCR5-engineered mesenchymal stromal cells home to spleen and mitigate post-sepsis syndrome by preventing secondary infection(Stem Cell Research & Therapy, IF = 7.3)
发表时间:2025-11-05
作者单位:中山大学附属第三医院
引用产品:Mouse IgG ELISA kit
样本类型:blood
原文链接:https://link.springer.com/article/10.1186/s13287-025-04751-2
11. Optimization of extraction process from Anemarrhena asphodeloides Bge. polysaccharide and its purification, structural characterization, and immunomodulatory activity(Journal of Future Foods, IF = 7.2)
发表时间:2025-11-12
作者单位:河北大学
引用产品:Mouse IL-6 ELISA kit、Mouse TNF-α ELISA kit
样本类型:RAW264.7 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S2772566925003428
12. A Mucoadhesive Hydrogel for Precise Resveratrol Delivery in the Management of Inflammatory Bowel Disease(Food Frontiers, IF = 6.9)
发表时间:2025-11-20
作者单位:深圳大学
引用产品:Mouse TNF-α ELISA kit、Mouse IL-6 ELISA kit
样本类型:colon tissue
原文链接:https://iadns.onlinelibrary.wiley.com/doi/abs/10.1002/fft2.70179
13. Prenatal electroacupuncture modulates maternal-fetal immune activation via a brain-to-splenic signal(Cell Reports, IF = 6.9)
发表时间:2025-11-17
作者单位:未明确提及
引用产品:Mouse IL-6 ELISA kit、Mouse CCL2/JE/MCP-1 ELISA kit
样本类型:serum, brain tissue, spleen tissue
原文链接:https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01348-8
14. A Novel Rhodotorula evergladensis CXCN-6 Rich in Torularhodin and PUFAs with Potent Antioxidant and Anti-Inflammatory Activities(Antioxidants, IF = 6.6)
发表时间:2025-11-27
作者单位:山东中医药大学针灸研究院、广州中医药大学
引用产品:Mouse IL-6 ELISA kit、Mouse TNF-α ELISA kit
样本类型:RAW 264.7 cell
原文链接:https://www.mdpi.com/2076-3921/14/12/1420
15. Single-cell transcriptome analysis profiles the enlarged subsets of myeloid-biased HSPCs with preleukemic characters in disuse osteoporosis mice(Cell and Bioscience, IF = 6.2)
发表时间:2025-11-12
作者单位:空军军医大学唐都医院
引用产品:Mouse TGF-β1 ELISA kit
样本类型:bone marrow (BM) fluid
原文链接:https://link.springer.com/article/10.1186/s13578-025-01499-3
16. Aflatoxin B1-induced lipid disturbance and neuroinflammation contribute to Alzheimer's disease-like neuropathology in C57BL/6J mice(ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, IF = 6.1)
发表时间:2025-11-30
作者单位:重庆大学
引用产品:Mouse IL-1β ELISA kit、Mouse IL-6 ELISA kit)、Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0147651325018408
17. IRF7 drives macrophages to kill bacteria and improves septic outcomes via autophagy(JCI Insight, IF = 6.1)
发表时间:2025-11-10
作者单位:南方医科大学、南方医科大学深圳医院、东莞市人民医院
引用产品:Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://insight.jci.org/articles/view/189420
18. S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway(JOURNAL OF CLINICAL IMMUNOLOGY, IF = 5.7)
发表时间:2025-11-15
作者单位:山东省耳鼻喉医院
引用产品:Human IL-6 ELISA kit、Human IL-8 ELISA kit
样本类型:human nasal epithelial cells
原文链接:https://link.springer.com/article/10.1007/s10875-025-01953-4
19. Tongmaijiangzhi formula and its hypolipidemic compounds attenuate hyperlipidemia and hepatic steatosis via AMPK/NF-κB pathway(JOURNAL OF ETHNOPHARMACOLOGY, IF = 5.4)
发表时间:2025-11-20
作者单位:厦门大学
引用产品:Human TNF-α ELISA kit、Human IL-6 ELISA kit
样本类型:HepG2 cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0378874125015892
20. Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation(JOURNAL OF ETHNOPHARMACOLOGY, IF = 5.4)
发表时间:2025-11-14
作者单位:江西中医药大学
引用产品:Human IL-6 ELISA kit、Human IL-8 ELISA kit
样本类型:MH7A cell
原文链接:https://www.sciencedirect.com/science/article/pii/S0378874125015958
21. In vitro and in vivo anti-inflammatory activity of oenothein B from Eucalyptus leaves and its amelioration mechanism on colitis mice by regulating fecal microbiota and metabolism(Food & Function, IF = 5.4)
发表时间:2025-11-26
作者单位:广东药科大学、华南农业大学、清华大学深圳国际研究生院
引用产品:Mouse IL-6 ELISA kit、Mouse IL-1β ELISA kit、Mouse TNF-α ELISA kit
样本类型:colon tissue, RAW 264.7 cell
原文链接:https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo03016a
22. The Frog Skin-Derived Antimicrobial Peptide Suppresses Atherosclerosis by Modulating the KLF12/p300 Axis Through miR-590-5p(INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, IF = 4.9)
发表时间:2025-11-27
作者单位:辽宁师范大学
引用产品:Human TNF-α ELISA kit、Human IL-6 ELISA kit、Human IL-1β ELISA kit
样本类型:THP-1 cell
原文链接:https://www.mdpi.com/1422-0067/26/23/11497
23. Distinct Immune Landscapes between Murine and Human Periodontitis(iScience, IF = 4.1)
发表时间:2025-11-14
作者单位:四川大学华西口腔医院
引用产品:Mouse IL-6 ELISA kit
样本类型:serum
原文链接:https://www.cell.com/iscience/fulltext/S2589-0042(25)02334-X
24. SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice(Journal of Inflammation Research, IF = 4.1)
发表时间:2025-11-18
作者单位:南通大学
引用产品:Mouse IL-1β ELISA kit、Mouse IL-6 ELISA kit、Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://www.tandfonline.com/doi/abs/10.2147/JIR.S559076
25. Empagliflozin alleviates lipid deposition and inflammation in diabetic kidney disease by downregulating C1QC(MOLECULAR AND CELLULAR BIOCHEMISTRY, IF = 3.7)
发表时间:2025-11-18
作者单位:襄阳市中心医院、恩施州中心医院
引用产品:Mouse IL-18 ELISA kit、Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://link.springer.com/article/10.1007/s11010-025-05437-2
26. Pathogenic and transcriptomic differences among porcine reproductive and respiratory syndrome viruses from distinct lineages in piglets(VETERINARY RESEARCH, IF = 3.5)
发表时间:2025-11-28
作者单位:华中农业大学
引用产品:Porcine IL-1β ELISA kit、Porcine IL-4 ELISA kit、Porcine IL-10 ELISA kit、Porcine TNF-α ELISA kit
样本类型:serum
原文链接:https://link.springer.com/article/10.1186/s13567-025-01659-w
27. A study on the establishment of a traumatic brain injury model of tree shrews and the observation of neuroinflammatory responses(IBRO Neuroscience Reports, IF = 2.9)
发表时间:2025-11-04
作者单位:昆明医科大学
引用产品:Rat TNF-α ELISA kit、Rat IL-6 ELISA kit、Rat IL-10 ELISA kit
样本类型:Plasma, brain tissue
原文链接:https://www.sciencedirect.com/science/article/pii/S2667242125001800
28. Pituitary adenylate cyclase-activating polypeptide (PACAP) attenuates diabetic cardiomyopathy via Nrf2/HO-1 antioxidant signaling and NF-κB-mediated inflammation suppression in streptozotocin-treated mice(NEUROPEPTIDES, IF = 2.7)
发表时间:2025-11-01
作者单位:南方医科大学第五附属医院
引用产品:Mouse TNF-α ELISA kit、Mouse IL-6 ELISA kit、Mouse IL-1β ELISA kit、Mouse IL-10 ELISA kit
样本类型:Cardiac tissue, serum
原文链接:https://www.sciencedirect.com/science/article/pii/S014341792500068X
29. A Comparative Study of Therapeutic Effects of Mannose and Umbilical Cord Mesenchymal Stem Cells in the Treatment of Late-Stage Diabetes(Advanced Therapeutics, IF = 2.6)
发表时间:2025-11-10
作者单位:西安市人民医院
引用产品:Mouse IL-1β ELISA kit、Mouse IL-6 ELISA kit、Mouse TNF-α ELISA kit、Mouse IFN-γ ELISA kit
样本类型:serum
原文链接:https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adtp.202500281
30. Prior dexamethasone exposure attenuates the therapeutic efficacy of mouse bone marrow-derived mesenchymal stem cells in experimental autoimmune encephalomyelitis by fostering a hostile immunological microenvironment(JOURNAL OF NEUROIMMUNOLOGY, IF = 2.5)
发表时间:2025-11-19
作者单位:陕西师范大学
引用产品:Mouse IFN-γ ELISA kit、Mouse IL-1β ELISA kit、Mouse IL-17A ELISA kit、Mouse TNF-α ELISA kit
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0165572825002954
31. GDF15 alleviates the severity of experimental autoimmune myocarditis by inhibiting B cells function(BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, IF = 2.2)
发表时间:2025-11-11
作者单位:华中科技大学同济医学院附属协和医院
引用产品:Mouse IgA ELISA kit、Mouse IgM ELISA kit、Mouse IgG ELISA kit
样本类型:serum
原文链接:https://www.sciencedirect.com/science/article/pii/S0006291X25016365
